NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Physiological and biochemical characteristics of adrenergic receptors and pathways in brown adipocytesMechanisms involved in the thermogenic response of brown adipose tissue (BAT) to sympathetic nervous stimulation (e.g., by cold exposure) and to norepinephrine (NE) release are investigated. Three effects appear to play a role in the increased oxygen consumption (and heat production) of the adipocytes: increased membrane permeability, activation of the beta-adrenergic pathway, and enhancement of Na(+)/K(+) membrane pump activity. Increased passive influx of Na(+) and efflux of K(+) due to greater permeability raise the energy demands of the Na/K pump; the pump is also stimulated by increased cyclic AMP synthesis resulting from activation by NE of membrane-bound adenyl cyclase. Studies with inhibitors such as propanolol, phentolamine, and ouabain support this hypothesis.
Document ID
19750055087
Document Type
Conference Proceedings
Authors
Horwitz, B. A. (California, University Davis, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1975
Subject Category
LIFE SCIENCES (GENERAL)
Meeting Information
Temperature regulation and drug action; Second Symposium on the Pharmacology of Thermoregulation(Paris)
Funding Number(s)
CONTRACT_GRANT: NSF GB-30594
CONTRACT_GRANT: NGR-05-004-035
Distribution Limits
Public
Copyright
Other