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The Acute Inhalation Toxicity in Rats from the Pyrolysis Products of Four FluoropolymersMale Sprague-Dawley rats (225?250 g) were exposed to the thermal degradation products from four fluoropolymers. The three polymers containing vinylidene fluoride and hexafluoropropene (VF2/HFP) were pyrolyzed at 550? and 800?C, whereas polytetrafluoroethylene (PTFE) was pyrolyzed at 625 and 800?C. At the lower temperatures, the pyrolysate from the copolymer of vinylidene fluoride and hexafluoropropene (VF2/HFP) was less toxic than the pyrolysates from either the terpolymer of vinyidene fluoride, hexafluoropropene, and tetrafluoroethylene (VF2/HFP/TFE) or the copolymer of vinylidene fluoride and hexafluoropropene with ?additives? (VF2/HFP-A). However, the pyrolysates from the VF2/HFP-containing materials produced less toxic products than the pyrolysate from PTFE at 625?C. When the pyrolysis temperature was increased to 800?C, very little difference was noted between the pyrolysis toxicity for any of the VF2/HFP-containing polymers with the most toxic pyrolysate again produced by PTFE. Carbon monoxide levels were all sublethal. No correlation could be established between hydrolyzable fluoride levels and the lethality of the pyrolysates. Death following exposure occurred within 48 hr due to acute pulmonary edema and hemorrhage. Survival of this acute phase was followed by alveolar lymphocytic infiltration and peribronchial tissue proliferation.
Document ID
19750055294
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
Authors
Carter, V. L., Jr.
Bafus, D. A.
Warrington, H. P.
Harris, E. S.
(NASA Johnson Space Center Incorporated Toxicology Laboratory, Houston, Tex., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1974
Publication Information
Publication: Toxicology and Applied Pharmacology
Volume: 30
Subject Category
Life Sciences (General)
Accession Number
75A39366
Distribution Limits
Public
Copyright
Other

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