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Record Details

Record 87 of 15417
Oligonucleotide synthesis catalyzed by the Zn/2+/ ion
Author and Affiliation:
Sawai, H.
Orgel, L. E.(Salk Institute for Biological Studies, San Diego, Calif., United States)
Abstract: Results of experiments are reported in which Zn(2+) ion catalyzed the formation of oligonucleotides from nucleoside phosphorimidazolides in aqueous solution, even in the absence of a template. Specifically, the imidazolides (ImpU or ImpA) polymerized to form ImpApA, and pApA, pApApA, and pApApApA, or the analogous uracil compounds. In addition, the expected hydrolysis products of the hydrolysis of ImpA were formed (pA, imidazole). Judging from the ratio of pA(n) over pA (with and without zinc ion), this ion increased the efficiency of phosphodiester-bond formation by up to 10 times. Possible mechanisms for the reaction are tentatively proposed.
Publication Date: Jan 01, 1975
Document ID:
19750063170
(Acquired Dec 01, 1995)
Accession Number: 75A47242
Subject Category: CHEMISTRY AND MATERIALS (GENERAL)
Document Type: Journal Article
Publication Information: American Chemical Society; vol. 97
Publisher Information: United States
Contract/Grant/Task Num: NGR-05-067-001
Financial Sponsor: NASA; United States
Description: 2p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ADENOSINES; BIOSYNTHESIS; CATALYSIS; NUCLEOTIDES; PHOSPHORUS COMPOUNDS; ZINC; AQUEOUS SOLUTIONS; CHEMICAL REACTIONS; CHLORIDES; METAL IONS; NUCLEIC ACIDS; POLYMERIZATION
Imprint And Other Notes: American Chemical Society, Journal, vol. 97, 1975, p. 3532, 3533.
Miscellaneous Notes: 1975, p. 3532, 3533
Availability Source: Other Sources
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