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Prostaglandin control of renal circulation in the unanesthetized dog and baboonEffects of indomethacin and meclofenamate, inhibitors of prostaglandin synthesis, were evaluated in the regulation of renal blood flow in conscious and anesthetized dogs and in tranquilized baboons, instrumented with arterial pressure catheters and renal blood flow probes. Indomethacin, 10 mg/kg, did not alter renal blood flow or resistance significantly in the conscious dog. In the anesthetized dog, however, indomethacin caused a reduction in renal blood flow and an elevation of renal vascular resistance. Meclofenamate, 4 mg/kg, reduced renal flow and increased renal vascular resistance in conscious dogs. In conscious dogs and tranquilized primates, indomethacin and meclofenamate reduced the reactive hyperemia in the renal bed. Methoxamine and angiotensin II infused in graded doses induced significantly greater renal vasoconstriction in conscious dogs in the presence of indomethacin. Thus, in the conscious animal, prostaglandins appear to play only a minor part in the control of renal circulation at rest, but they are of greater importance in mediating the renal responses to reactive hyperemia and to vasoconstriction.
Document ID
19760027132
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Swain, J. A.
(Childrens Hospital Medical Center Boston, MA, United States)
Vatner, S. F.
(Harvard University; Peter Bent Brigham Hospital; Children's Hospital Medical Center Boston; New England Regional Primate Research Center, Southborough, Mass., United States)
Heyndrickx, G. R.
(Childrens Hospital Medical Center Boston, MA, United States)
Boettcher, D. H.
(Childrens Hospital Medical Center Boston, MA, United States)
Date Acquired
August 8, 2013
Publication Date
September 1, 1975
Publication Information
Publication: American Journal of Physiology
Volume: 229
Subject Category
Life Sciences (General)
Accession Number
76A10098
Funding Number(s)
CONTRACT_GRANT: PHS-HL-15416
CONTRACT_GRANT: PHS-HL-17549
CONTRACT_GRANT: PHS-HL-1043609
Distribution Limits
Public
Copyright
Other

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