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Record 1 of 1182
Renal effects of continuous negative pressure breathing
Author and Affiliation:
Kinney, M. J.(U.S. Public Health Service Hospital, Staten Island, N.Y., United States)
Abstract: Continuous negative pressure breathing (CNPB) was utilized to simulate the thoracic vascular distension of zero G in 11 anesthetized rats. The animals underwent renal clearance and micropuncture renal nephron studies before, during, and after CNPB. Four rats were pretreated with a high salt diet and I-M desoxycorticosterone (DOCA) in excess. None of these rats diuresed with CNPB. In contrast, five of the seven remaining rats increased the fraction of the filtered sodium excreted and their urinary flow rate. Potassium excretion increased. End proximal tubular fluid specimen's TF/P inulin ratios were unchanged. Whole kidney and single nephron glomerular filtration rates fell 10%. CNPB, a mechanism for atrial distension, appears to cause in the rat a decrease in distal tubular sodium and water reabsorption. Exogenous mineral-corticoid prevents the diuresis, saluresis, and kaluresis. The adequacy of other nonatrial volume control mechanisms in regulating renal salt and water conservation in opposition to the studied atrial-renal (Henry-Gauer) reflex of thoracic vascular distension is confirmed.
Publication Date: Nov 01, 1975
Document ID:
19760030615
(Acquired Dec 01, 1995)
Accession Number: 76A13581
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publisher Information: United States
Contract/Grant/Task Num: PHS PROJECT SI-75-32-73; NASA ORDER T-2950-A
Financial Sponsor: NASA; United States
Organization Source: Public Health Service Hospital; Staten Island, NY, United States
Description: 5p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: PRESSURE BREATHING; RENAL FUNCTION; SPACE ENVIRONMENT SIMULATION; WEIGHTLESSNESS; ARTERIES; BLOOD VOLUME; CARDIAC VENTRICLES; CORONARY CIRCULATION; DIURESIS; RATS; SALTS; URINE
Imprint And Other Notes: Aviation, Space, and Environmental Medicine, vol. 46, Nov. 1975, p. 1358-1362.
Availability Source: Other Sources
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