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Effect of fluorocarbons on acetylcholinesterase activity and some counter measuresAn isolated vagal sympathetic heart system has been successfully used for the study of the effect of fluorocarbons (FCs) on cardiac performance and in situ enzyme activity. Dichlorodifluoromethane sensitizes this preparation to sympathetic stimulation and to exogenous epinephrine challenge. Partial and complete A-V block and even cardiac arrest have been induced by epinephrine challenge in the FC sensitized heart. Potassium chloride alone restores the rhythmicity but not the normal contractility of the heart in such a situation. Addition of glucose will, however, completely restore the normal function of the heart which is sensitized by dichlorodifluoromethane. The ED 50 values of acetylcholinesterase activity which are used as a measure of relative effectiveness of fluorocarbons are compared with the maximum permissible concentration. Kinetic studies indicate that all the fluorocarbons tested so far are noncompetitive.
Document ID
19760034930
Document Type
Reprint (Version printed in journal)
Authors
Young, W. (NASA Ames Research Center Moffett Field, CA, United States)
Parker, J. A. (NASA Ames Research Center Moffett Field, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
November 1, 1975
Publication Information
Publication: Journal of Fire and Flammability
Subject Category
AEROSPACE MEDICINE
Distribution Limits
Public
Copyright
Other