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Histamine H2 receptor - Involvement in gastric ulcerationThe involvement of the H1 and H2 receptors for histamine in the pathogenesis of gastric ulcers was investigated in rats. Metiamide, an H2 receptor antagonist, reliably reduced ulceration produced by stress alone or by a combination of stress and aspirin. In contrast, pyrilamine, which blocks only the H1 receptor, was without effect under these same conditions. The results support the hypothesis that histamine mediates both stress and stress plus aspirin induced ulceration by a mechanism involving the H2 receptor.
Document ID
19760044946
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Brown, P. A.
(NASA Ames Research Center Moffett Field, CA, United States)
Vernikos-Danellis, J.
(NASA Ames Research Center Biomedical Research Div., Moffett Field, Calif., United States)
Brown, T. H.
(NASA Ames Research Center Biomedical Research Div., Moffett Field; Stanford University, Stanford, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1976
Publication Information
Publication: Life Sciences
Volume: 18
Subject Category
Life Sciences (General)
Accession Number
76A27912
Distribution Limits
Public
Copyright
Other

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