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Effects of high-LET particles /A-40/ on the brain of Drosophila melanogasterTo investigate the effects of galactic heavy particles on nervous tissue, Drosophila melanogaster flies were exposed to A-40 from the Super-HILAC accelerator at the Lawrence Berkeley Laboratory. The energy of the particles reaching the Drosophila neurons was 4.8 MeV/nucleon, and the fluence ranged from 60,000 to 80 million particles/sq cm. Thirty-five days after irradiation at the higher fluences, extensive tissue fragmentation and cysts were found. At fluences as low as one hit/two cell bodies (about 5 million) and one hit/90 cell bodies (about 90,000 particles/sq cm or 21 rad average dose) swelling of neuronal cytoplasm and focally fragmented membranes were noted; at fluences ranging from one hit/six to one hit/135 cell bodies, there was frequently a marked increase in glial lamellae around nerve-cell processes, which often had degenerative features. These findings support the view that single hits by heavy particles may injure nervous tissue.
Document ID
Document Type
Reprint (Version printed in journal)
Miquel, J. (NASA Ames Research Center Moffett Field, Calif., United States)
Herman, M. M. (Stanford University Stanford, Calif., United States)
Benton, E. V. (San Francisco, University San Francisco, Calif., United States)
Welch, G. (California, University Berkeley, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1976
Publication Information
Publication: International Journal of Radiation Biology
Volume: 29
Issue: 2, 19
Subject Category
Funding Number(s)
Distribution Limits