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The prebiotic synthesis of deoxythymidine oligonucleotides. II - Comparison of condensing agentsA reaction which oligomerizes nucleotides under possible prebiotic conditions has been characterized. Nucleoside monophosphate in the presence of cyanamide at acid pH condenses to form dithymidine pyrophosphate and phosphodiester bonded compounds. Imidazole compounds and activated precursors such as nucleoside triphosphate are not necessary for this oligomerization reaction which produces primarily cyclic oligonucleotides.
Document ID
19760057168
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Odom, D. G.
(Letterman Army Inst. of Research San Francisco, CA, United States)
Brady, J. T.
(U.S. Army, Letterman Army Institute of Research, San Francisco Calif., United States)
Date Acquired
August 8, 2013
Publication Date
November 4, 1975
Publication Information
Publication: Journal of Molecular Evolution
Volume: 6
Subject Category
Life Sciences (General)
Accession Number
76A40134
Distribution Limits
Public
Copyright
Other

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