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Formation of nucleoside 5'-polyphosphates from nucleotides and trimetaphosphateNucleoside 5'-polyphosphates (N5PP) formed when solutions of nucleoside 5'-phosphates (N5P) and trimetaphosphate (TMP) are dessicated at room temperature are studied by paper chromatography, electrophoresis, and metal catalytic reactions. Divalent Mg ion exhibited superior catalytic function to other divalent metal ions in the reaction. Major reaction products are indicated. The importance of the N5PP series, TMP, and N5-triphosphate as substrates of RNA and DNA synthesis, and under postulated prebiotic conditions likely to obtain during prebiological ages of the earth, is emphasized and discussed. Alternate drying and wetting, evaporation from a prebiotic puddle, concentration of solubles in the remaining liquid phase, metal catalysis, and the role of these substances in the formation of amino acids and long-chain polyphosphates are considered.
Document ID
19760057170
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Lohrmann, R.
(Salt Institute for Biological Studies San Diego, Calif., United States)
Date Acquired
August 8, 2013
Publication Date
December 29, 1975
Publication Information
Publication: Journal of Molecular Evolution
Volume: 6
Subject Category
Life Sciences (General)
Accession Number
76A40136
Funding Number(s)
CONTRACT_GRANT: NIH-GM-13435
Distribution Limits
Public
Copyright
Other

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