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Observations on autoregulation in skeletal muscle - The effects of arterial hypoxiaAn experimental study was carried out on 25 mongrel dogs of both sexes to re-evaluate autoregulation of blood flow in skeletal muscle, with particular reference to the steady-state resistance and transient response in muscle blood flow following a square wave increase in arterial perfusion pressure and to the examination of the effect of arterial hypoxia on this transient response. The data emphasize the importance of considering the transient changes in blood flow in evaluating the autoregulatory response in skeletal muscle. For quantification purposes, a parameter termed alpha is introduced which represents the ratio between the increase in blood flow from baseline to peak and the return of blood flow from the peak to the new steady-state. Such a quantification of the transient response in flow with step increases in perfusion pressure demonstrates substantial transient responses under conditions of normal oxygenation and progressive attenuation of flow transients with increasing hypoxia.
Document ID
19760058176
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Pohost, G. M.
(Harvard Univ. Boston, MA, United States)
Newell, J. B.
(Harvard Univ. Boston, MA, United States)
Hamlin, N. P.
(Harvard Univ. Boston, MA, United States)
Powell, W. J., Jr.
(Massachusetts General Hospital; Harvard University Boston, Mass., United States)
Date Acquired
August 8, 2013
Publication Date
July 1, 1976
Publication Information
Publication: Cardiovascular Research
Volume: 10
Subject Category
Life Sciences (General)
Accession Number
76A41142
Funding Number(s)
CONTRACT_GRANT: NIH-HL-06665
Distribution Limits
Public
Copyright
Other

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