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Hypergravity effects on normal and avulsed developing avian radiiRhode Island red female chicks were subjected to complete closed fracture of the right radius at 2 weeks post-hatching. The animals were allowed to heal for 1 week at either earth-gravity or 2-G-hypergravity state with control and estrogen-injected groups. Intact and fractured radial length, weight, average epiphysial-diaphysial diameters, and length, width, and weight of healing fracture callus were measured. Daily 2000 IU estrogen administration for 7 d increased intact radial length. Estrogen augments the effects of the 2-G state by inhibiting growth and depleting the mass of both intact and fractured radii and by decreasing the average distal epiphysial diameter of fractured bones. Animals exposed to the hypergravity state without hormonal treatment showed decreased fractured radial length, weight, and smaller proximal epiphysial diameters. The measurable parameters of the fracture callus (width, length, and weight) were depressed by the hypergravity state regardless of whether the animal was untreated or supplemented with estrogen.
Document ID
19760058544
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Negulesco, J. A.
(Ohio State Univ. Columbus, OH, United States)
Clark, D. L.
(Ohio State University Columbus, Ohio, United States)
Date Acquired
August 8, 2013
Publication Date
August 1, 1976
Subject Category
Life Sciences (General)
Accession Number
76A41510
Funding Number(s)
CONTRACT_GRANT: NIH-5409
CONTRACT_GRANT: NAS2-6634
Distribution Limits
Public
Copyright
Other

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