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Mechanisms of radio-protection by catecholamines in the hamster /Mesocricetus auratus/Experiments were conducted on normal and splenectomized male and female hamsters between 2 and 3 months old subjected to a whole-body exposure of 1000 or 2000 rads in a Co-60 source with a view toward evaluating their radio-protection by norepinephrine, isoproterenol, and phenylephrine. Vasoconstriction hypoxia mechanism of radio-protection is examined along with the hypothesis that isoproterenol protects by hypercalcemia-induced cell proliferation. Radiation experiment results are found to be consistent with the hypothesis that stimulation of alpha receptors results in radio-protection through a tissue hypoxia mechanism. Beta agonists seem to protect by a hypotensive-hypoxia mechanism. The catecholamines protect against the hematopoietic syndrome, but show no evidence of protection against the gastrointestinal syndrome.
Document ID
19760064755
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Prewitt, R. L.
(Missouri Univ. Columbia, MO, United States)
Musacchia, X. J.
(Missouri, University Columbia, Mo., United States)
Date Acquired
August 8, 2013
Publication Date
January 1, 1975
Publication Information
Publication: International Journal of Radiation Biology
Volume: 27
Issue: 2, 19
Subject Category
Life Sciences (General)
Accession Number
76A47721
Funding Number(s)
CONTRACT_GRANT: PHS-GM-41418-03
CONTRACT_GRANT: NGL-26-004-021
Distribution Limits
Public
Copyright
Other

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