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Record Details

Record 20 of 697
Mechanisms of radio-protection by catecholamines in the hamster /Mesocricetus auratus/
Author and Affiliation:
Prewitt, R. L.(Missouri Univ., Columbia, MO, United States)
Musacchia, X. J.(Missouri, University, Columbia, Mo., United States)
Abstract: Experiments were conducted on normal and splenectomized male and female hamsters between 2 and 3 months old subjected to a whole-body exposure of 1000 or 2000 rads in a Co-60 source with a view toward evaluating their radio-protection by norepinephrine, isoproterenol, and phenylephrine. Vasoconstriction hypoxia mechanism of radio-protection is examined along with the hypothesis that isoproterenol protects by hypercalcemia-induced cell proliferation. Radiation experiment results are found to be consistent with the hypothesis that stimulation of alpha receptors results in radio-protection through a tissue hypoxia mechanism. Beta agonists seem to protect by a hypotensive-hypoxia mechanism. The catecholamines protect against the hematopoietic syndrome, but show no evidence of protection against the gastrointestinal syndrome.
Publication Date: Jan 01, 1975
Document ID:
19760064755
(Acquired Dec 01, 1995)
Accession Number: 76A47721
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: International Journal of Radiation Biology; 27; 2, 19; 1975
Publisher Information: United Kingdom
Contract/Grant/Task Num: PHS-GM-41418-03; NGL-26-004-021
Financial Sponsor: NASA; United States
Organization Source: Missouri Univ.; Columbia, MO, United States
Description: 11p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ANTIRADIATION DRUGS; CATECHOLAMINE; RADIATION SICKNESS; RADIOBIOLOGY; BLOOD PLASMA; BLOOD PRESSURE; CALCIUM; COBALT 60; HAMSTERS; HYPOXIA; MORTALITY; PHARMACOLOGY; RECEPTORS (PHYSIOLOGY); SPLEEN; VASOCONSTRICTION
Imprint And Other Notes: International Journal of Radiation Biology, vol. 27, no. 2, 1975, p. 181-191.
Miscellaneous Notes: p. 181-1
Availability Source: Other Sources
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