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A role for glucose in hypothermic hamstersHypothermic hamsters at a rectal temperature of 7 C showed a fivefold increase in survival times from 20 to 100.5 hr when infused with glucose which maintained a blood level at about 45 mg/100 ml. A potential role for osmotic effects of the infusion was tested and eliminated. There was no improvement in survival of 3-O-methylglucose or dextran 40-infused animals. The fact that death eventually occurs even in the glucose-infused animal after about 4 days and that oxygen consumption undergoes a slow decrement in that period suggests that hypothermic survival is not wholly substrate limited. Radioactive tracer showed that localization of the C-14 was greatest in brain tissue and diaphragm, intermediate in heart and kidney, and lowest in skeletal muscle and liver. The significance of the label at sites important to respiration and circulation was presented.
Document ID
19770034448
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Resch, G. E.
(Missouri Univ. Columbia, MO, United States)
Musacchia, X. J.
(Missouri-Columbia, University Columbia, Mo., United States)
Date Acquired
August 9, 2013
Publication Date
December 1, 1976
Publication Information
Publication: American Journal of Physiology
Volume: 231
Subject Category
Life Sciences (General)
Accession Number
77A17300
Funding Number(s)
CONTRACT_GRANT: NGL-26-004-021
Distribution Limits
Public
Copyright
Other

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