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Origins of serotonin innervation of forebrain structuresThe tryptophan hydroxylase activity and high-affinity uptake of (3H) serotonin ((3H)5-HT) were measured in five discrete brain regions of rats following lesions of the dorsal or median raphe nuclei. Dorsal raphe lesions reduced enzyme and uptake activity in the striatum only. Median raphe lesions reduced activities in the hippocampus, septal area, frontal cortex, and, to a lesser extent, in the hypothalamus. These data are consistent with the suggestion that the dorsal and median raphe nuclei are the origins of two separate ascending serotonergic systems - one innervating striatal structures and the other mesolimbic structures, predominantly. In addition, the data suggest that measurements of high-affinity uptake of (3H)5-HT may be a more reliable index of innervation than either 5-HT content or tryptophan hydroxylase activity.
Document ID
19770068765
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kellar, K. J.
(NASA Ames Research Center Moffett Field, CA, United States)
Brown, P. A.
(NASA Ames Research Center Moffett Field, CA, United States)
Madrid, J.
(NASA Ames Research Center Moffett Field, CA, United States)
Bernstein, M.
(NASA Ames Research Center Moffett Field, CA, United States)
Vernikos-Danellis, J.
(NASA Ames Research Center Moffett Field, CA, United States)
Mehler, W. R.
(NASA Ames Research Center Biomedical Research Div., Moffett Field, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
July 1, 1977
Publication Information
Publication: Experimental Neurology
Volume: 56
Subject Category
Life Sciences (General)
Accession Number
77A51617
Distribution Limits
Public
Copyright
Other

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