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New microbial growth factorA screening procedure was used to isolate from soil a Penicillium sp., two bacterial isolates, and a Streptomyces sp. that produced a previously unknown microbial growth factor. This factor was an absolute growth requirement for three soil bacteria. The Penicillium sp. and one of the bacteria requiring the factor, an Arthrobacter sp., were selected for more extensive study concerning the production and characteristics of the growth factor. It did not seem to be related to the siderochromes. It was not present in soil extract, rumen fluid, or any other medium component tested. It appears to be a glycoprotein of high molecular weight and has high specific activity. When added to the diets for a meadow-vole mammalian test system, it caused an increased consumption of diet without a concurrent increase in rate of weight gain.
Document ID
Document Type
Reprint (Version printed in journal)
Bok, S. H.
(Pennsylvania State Univ. University Park, PA, United States)
Casida, L. E., Jr.
(Pennsylvania State University University Park, Pa., United States)
Date Acquired
August 9, 2013
Publication Date
May 1, 1977
Publication Information
Publication: Applied and Environmental Microbiology
Volume: 33
Subject Category
Life Sciences (General)
Accession Number
Funding Number(s)
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