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Renal sodium reabsorption following induction of and recovery from volume expansionIn the rat, infusion of a volume of isotonic saline equal to 2% of body weight resulted in an 82% increase in the delivery of filtrate out of the proximal tubule but little or, in some animals, no change in the urinary excretion of sodium. By contrast, further degrees of volume expansion resulted in lesser increases in the distal delivery of filtrate, but were associated with a marked increase in the urinary excretion of sodium. Sixty minutes following completion of volume expansion, while the animals were still in positive sodium balance, the urinary excretion of sodium decreased 52% compared to a decrease of only 24% in the distal delivery of filtrate. During the course of progressive volume expansion and during the recovery phase, there was a dissociation between alterations in sodium reabsorption in the proximal convoluted tubule and in the whole kidney. These studies indicate that although the proximal tubule is more sensitive to changes in the extracellular fluid volume, distal nephron sites are ultimately responsible both for the natriuresis of volume expansion and the relative antinatriuresis of the recovery periods.
Document ID
19780033738
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Knight, T. F.
(U.S. Veterans Administration Hospital Houston, Tex., United States)
Weinman, E. J.
(Baylor University Houston, Tex., United States)
Date Acquired
August 9, 2013
Publication Date
November 1, 1977
Publication Information
Publication: American Journal of Physiology
Volume: 233
Subject Category
Life Sciences (General)
Accession Number
78A17647
Funding Number(s)
CONTRACT_GRANT: NAS9-14715
Distribution Limits
Public
Copyright
Other

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