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Record Details

Record 5 of 1182
Emptying patterns of the lung studied by multiple-breath N2 washout
Author and Affiliation:
Lewis, S. M.(California, University, La Jolla, Calif., United States)
Abstract: Changes in the nitrogen concentration seen during the single-breath nitrogen washout reflect changes in relative flow (ventilation) from units with differing ventilation/volume ratios. The multiple-breath washout provides sufficient data on ventilation for units with varying ventilation/volume ratios to be plotted as a function of the volume expired. Flow from the dead space may also be determined. In young normals the emptying patterns are narrow and unimodal throughout the alveolar plateau with little or no flow from the dead space at the end of the breath. Older normals show more flow from the dead space, particularly toward the end of the breath, and some show a high ventilation/volume ratio mode early in the breath. Patients with obstructive lung disease have a high flow from the dead space which is present throughout the breath. A well ventilated mode at the end of the breath is seen in some obstructed subjects. Patients with cystic fibrosis showed a poorly ventilated mode appearing at the end of the breath as well as a very high dead space.
Publication Date: Mar 01, 1978
Document ID:
19780045125
(Acquired Dec 01, 1995)
Accession Number: 78A29034
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Journal of Applied Physiology: Respiratory; p. vol. 44
Publisher Information: United States
Contract/Grant/Task Num: PHS-HL-17731; NIH-HL-14152; PHS-IT-32-HL-07212-01; PHS-HL-05831-04; NGL-05-009-109
Financial Sponsor: NASA; United States
Organization Source: California Univ.; La Jolla, CA, United States
Description: 7p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BIOMETRICS; NITROGEN; PULMONARY FUNCTIONS; VENTILATION; VOLUMETRIC ANALYSIS; CYSTIC FIBROSIS; GAS ANALYSIS; MATHEMATICAL MODELS; OXYGEN BREATHING; RESPIRATORY DISEASES; RESPIRATORY PHYSIOLOGY
Imprint And Other Notes: Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, vol. 44, Mar. 1978, p. 424-430.
Miscellaneous Notes: Mar. 1978, p. 424-430
Availability Source: Other Sources
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