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Controlled cellular energy conversion in brown adipose tissue thermogenesisBrown adipose tissue serves as a model system for nonshivering thermogenesis (NST) since a) it has as a primary physiological function the conversion of chemical energy to heat; and b) preliminary data from other tissues involved in NST (e.g., muscle) indicate that parallel mechanisms may be involved. Now that biochemical pathways have been proposed for brown fat thermogenesis, cellular models consistent with a thermodynamic representation can be formulated. Stated concisely, the thermogenic mechanism in a brown fat cell can be considered as an energy converter involving a sequence of cellular events controlled by signals over the autonomic nervous system. A thermodynamic description for NST is developed in terms of a nonisothermal system under steady-state conditions using network thermodynamics. Pathways simulated include mitochondrial ATP synthesis, a Na+/K+ membrane pump, and ionic diffusion through the adipocyte membrane.
Document ID
19780068789
Document Type
Reprint (Version printed in journal)
Authors
Horowitz, J. M. (California Univ. Davis, CA, United States)
Plant, R. E. (California, University Davis, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
September 1, 1978
Publication Information
Publication: American Journal of Physiology
Volume: 235
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NIH-AM-16716
CONTRACT_GRANT: NGR-05-004-099
Distribution Limits
Public
Copyright
Other