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A study of axonal degeneration in the optic nerves of aging miceThe optic nerves of C57BL/6J mice ranging from 3 to 30 months were examined by electron microscopy. At all ages investigated, optic nerve axons contained enlarged mitochondria with abnormal cristae. With increasing age, a large number of necrotic axons were observed and were in the process of being phagocytized. The abnormal mitochondria may represent preliminary changes that eventually lead to necrosis of the axon.
Document ID
19790028110
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Johnson, J. E., Jr. (NASA Ames Research Center Moffett Field, CA, United States)
Philpott, D. E. (NASA Ames Research Center Moffett Field, CA, United States)
Miquel, J. (NASA Ames Research Center Biomedical Research Div., Moffett Field, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
April 1, 1978
Publication Information
Publication: Age
Volume: 1
Subject Category
Life Sciences (General)
Accession Number
79A12123
Distribution Limits
Public
Copyright
Other

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