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The REH theory of protein and nucleic acid divergence - A retrospective updateThe random evolutionary hits (REH) theory of evolutionary divergence, originally proposed in 1972, is restated with attention to certain aspects of the theory that have caused confusion. The theory assumes that natural selection and stochastic processes interact and that natural selection restricts those codon sites which may fix mutations. The predicted total number of fixed nucleotide replacements agrees with data for cytochrome c, a-hemoglobin, beta-hemoglobin, and myoglobin. The restatement analyzes the magnitude of possible sources of errors and simplifies calculational methodology by supplying polynomial expressions to replace tables and graphs.
Document ID
19790036253
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Holmquist, R.
(California, University Berkeley, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
October 6, 1978
Publication Information
Publication: Journal of Molecular Evolution
Volume: 11
Subject Category
Chemistry And Materials (General)
Accession Number
79A20266
Funding Number(s)
CONTRACT_GRANT: NSF PCM-76-18627
CONTRACT_GRANT: PHS-HL-11553-06
CONTRACT_GRANT: NGR-05-003-460
Distribution Limits
Public
Copyright
Other

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