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The augmentation algorithm and molecular phylogenetic treesMoore's (1977) augmentation procedure is discussed, and it is concluded that the procedure is valid for obtaining estimates of the total number of fixed nucleotide substitutions both theoretically and in practice, for both simulated and real data, and in agreement, for experimentally dense data sets, with stochastic estimates of the divergence, provided the restrictions on codon mutability resulting from natural selection are explicitly allowed for. Tateno and Nei's (1978) critique that the augmentation procedure has a systematic bias toward overestimation of the total number of nucleotide replacements is disputed, and a data analysis suggests that ancestral sequences inferred by the method of parsimony contain a large number of incorrectly assigned nucleotides.
Document ID
19790036254
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Holmquist, R. (California, University Berkeley, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
October 27, 1978
Publication Information
Publication: Journal of Molecular Evolution
Volume: 12
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NGR-05-003-460
CONTRACT_GRANT: NSF PCM-76-18627
Distribution Limits
Public
Copyright
Other