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Senescent changes in the ribosomes of animal cells in vivo and in vitroThe paper examines RNA-ribosomal changes observed in protozoa and fixed postmitotic cells, as well as the characteristics of intermitotic cells. Attention is given to a discussion of the implications of the reported ribosomal changes as to the senescent deterioration of protein synthesis and physiological functions. A survey of the literature suggests that, while the data on ribosomal change in dividing cells both in vivo and in vitro are inconclusive, there is strong histological and biochemical evidence in favor of some degree of quantitative ribosomal loss in fixed postmitotic cells. Since these decreases in ribosomes are demonstrated in differential cells from nematodes, insects and mammals, they may represent a universal manifestation of cytoplasmic senescence in certain types of fixed postmitotic animal cells. The observed variability in ribosomal loss for cells belonging to the same type suggests that this involution phenomenon is rather related to the wear and tear suffered by a particular cell.
Document ID
Document Type
Reprint (Version printed in journal)
Miquel, J.
(NASA Ames Research Center Moffett Field, Calif., United States)
Johnson, J. E., Jr.
(National Institutes of Health, National Institute on Aging; Baltimore City Hospital, Baltimore Md., United States)
Date Acquired
August 9, 2013
Publication Date
January 1, 1979
Publication Information
Publication: Mechanisms of Ageing and Development
Volume: 9
Subject Category
Life Sciences (General)
Distribution Limits
No Preview Available