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RBC-/Cr-51/ half-life and albumin turnover in growing Beagle dogs during chronic radial accelerationThe effects of chronic centrifugation on growing Beagle dogs exposed to -2 or -2.6 Gx on albumin and RBC turnover rates, albumin concentration and space, and total blood volume were determined and compared with caged and run control of animals. Albumin-(I-125) and autologous RBC-(Cr-51) preparations were injected into all dogs at day 82 of the centrifugation periods, and the disappearance curves were determined by successive bleedings of the animals over the next 35 d, during which the centrifugation was continued. There were no differences in albumin turnover rates or space. Two populations of RBCs were found in both centrifugated groups, one with a normal half-life of 27 + or - 1 S.E.M. d, and one with a significantly (p less than 0.01) shorter half-life of 15 + or - 2 S.E.M. d. An absolute polycythemia was also observed in both centrifuged groups. The results suggest that chronic centrifugation acts through some as-yet unknown mechanism to affect RBC population kinetics.
Document ID
19790043540
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Beckman, D. A.
(California Univ. Davis, CA, United States)
Evans, J. W.
(California, University Davis, Calif., United States)
Oyama, J.
(NASA Ames Research Center Biomedical Research Div., Moffett Field; California, University, Davis, Calif., United States)
Date Acquired
August 9, 2013
Publication Date
March 1, 1979
Subject Category
Life Sciences (General)
Accession Number
79A27553
Funding Number(s)
CONTRACT_GRANT: NCA2-OR180-505
Distribution Limits
Public
Copyright
Other

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