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Tissue gas and blood analyses of human subjects breathing 80% argon and 20% oxygenEight human volunteers, individually studied in a hyperbaric chamber, breathed: (1) air at 1 ATA; (2) 80% argon and 20% oxygen at 1 ATA for 30 min; (3) air at 1 ATA for 30 min; (4) 100% O2 at 1 ATA for 30 min; (5) air at 1 ATA for 30 min; (6) 100% O2 at 2 ATA for 60 min; and (7) 80% argon and 20% oxygen at 1 ATA for 30 min. Oxygen, carbon dioxide, nitrogen, and argon tensions were measured in muscle and subcutaneous tissue by mass spectroscopic analyses. Venous blood obtained at regular intervals was analyzed for coagulation and fibrinolytic factors. Inert gas narcosis was not observed. After breathing argon for 30 min, muscle argon tensions were almost three times the subcutaneous tensions. Argon wash-in mirrored nitrogen wash-out. Argon wash-in and wash-out had no effect on tissue PO2 or PCO2. Coagulation and fibrinolytic changes usually associated with vascular bubbles were absent.
Document ID
19790046642
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Horrigan, D. J.
(Texas Univ. Galveston, TX, United States)
Wells, C. H.
(Texas Univ. Galveston, TX, United States)
Guest, M. M.
(Texas Univ. Galveston, TX, United States)
Hart, G. B.
(Texas Univ. Galveston, TX, United States)
Goodpasture, J. E.
(NASA Johnson Space Center Medical Research Branch, Houston; Texas, University, Galveston, Tex., United States)
Date Acquired
August 9, 2013
Publication Date
April 1, 1979
Subject Category
Aerospace Medicine
Accession Number
79A30655
Distribution Limits
Public
Copyright
Other

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