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The point mutation process in proteinsAn optimized scoring matrix for residue-by-residue comparisons of distantly related protein sequences has been developed. The scoring matrix is based on observed exchanges and mutabilities of amino acids in 1572 closely related sequences derived from a cross-section of protein groups. Very few superimposed or parallel mutations are included in the data. The scoring matrix is most useful for demonstrating the relatedness of proteins between 65 and 85% different.
Document ID
19790053959
Document Type
Conference Proceedings
Authors
Schwartz, R. M. (National Biomedical Research Foundation Silver Spring, Md., United States)
Dayhoff, M. O. (National Biomedical Research Foundation, Silver Spring, Md.; Georgetown University Washington, D.C., United States)
Date Acquired
August 9, 2013
Publication Date
January 1, 1978
Subject Category
LIFE SCIENCES (GENERAL)
Meeting Information
Origin of life; Second ISSOL Meeting and Fifth ICOL Meeting(Kyoto)
Funding Number(s)
CONTRACT_GRANT: NASW-3019
CONTRACT_GRANT: NIH-RR-05681
CONTRACT_GRANT: NIH-GM-08710
Distribution Limits
Public
Copyright
Other