NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Synthesis of amino acyl adenylates using the tert-butoxycarbonyl protecting groupThe synthesis of amino acyl adenylates using N-tert-butoxycarbonyl-protected amino acids is reported. Anhydrous solutions containing N-tert-butoxycarbonyl alanine, phenylalanine, and methionine were combined with the anhydrous mono (tri-n-octylammonium) salt of adenosine 5'-phosphate and the resultant amino acyl adenylates were characterized by means of elemental analysis, and infrared and proton NMR spectroscopy. Amino acyl adenylate yields of up to 60% were obtained with high purity at room temperatures. The reported synthesis is considered to represent a large improvement over previous methods due to the purity of the products, normal temperature requirements, and the stability of the starting compounds, which suggests its use in investigations of prebiotic oligo- and polypeptide synthesis.
Document ID
19790061629
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Armstrong, D. W.
(Texas A&M Univ. College Station, TX, United States)
Seguin, R.
(Texas A&M Univ. College Station, TX, United States)
Saburi, M.
(Texas A&M Univ. College Station, TX, United States)
Fendler, J. H.
(Texas A & M University College Station, Tex., United States)
Date Acquired
August 9, 2013
Publication Date
July 18, 1979
Publication Information
Publication: Journal of Molecular Evolution
Volume: 13
Subject Category
Chemistry And Materials (General)
Accession Number
79A45642
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available