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Recovery of skeletal muscle after 3 mo of hindlimb immobilization in ratsDuring immobilization, skeletal muscle undergoes decreases in size and strength with concomitant atrophic and degenerative changes in slow-twitch muscle fibers. Currently there are no objective data in slow-twitch muscle demonstrating recovery of biochemical or physiological indices following termination of immobilization. The purpose of this study was to determine whether the soleus, a slow-twitch muscle, could recover normal biochemical or physiological levels following termination of immobilization. Adenosine triphosphate, glycogen, and protein concentration (mg/g wet wt) all significantly decreased following 90 days of hindlimb immobilization, but these three values returned to control levels by the 60th recovery day. Similarly, soleus muscle wet weight and protein content (mg protein/muscle) returned to control levels by the 14th recovery day. In contrast, maximal isometric tension did not return to normal until the 120th day. These results indicate that following muscular atrophy, which was achieved through 90 days of hindlimb immobilization, several biochemical and physiological values in skeletal muscle are recovered at various times after the end of immobilization.
Document ID
19790063843
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Booth, F. W.
(Texas Univ. Houston, TX, United States)
Seider, M. J.
(Texas, University Houston, Tex., United States)
Date Acquired
August 9, 2013
Publication Date
August 1, 1979
Publication Information
Publication: Journal of Applied Physiology: Respiratory
Subject Category
Life Sciences (General)
Accession Number
79A47856
Funding Number(s)
CONTRACT_GRANT: NAS9-15338
Distribution Limits
Public
Copyright
Other

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