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Piracetam and fish orientation during parabolic aircraft flightGoldfish were flown in parabolic Keplerian trajectories in a KC-135 aircraft to assay both the effectiveness of piracetam as an antimotion sickness drug and the effectiveness of state-dependent training during periods of oscillating gravity levels. Single-frame analyses of infrared films were performed for two classes of responses - role rates in hypogravity or hypogravity orienting responses (LGR) and climbing responses in hypergravity or hypergravity orienting responses (HGR). In Experiment I, preflight training with the vestibular stressor facilitated suppression of LGR by the 10th parabola. An inverse correlation was found between the magnitudes of LGR and HGR. Piracetam was not effective in a state-dependent design, but the drug did significantly increase HGR when injected into trained fish shortly before flight. In Experiment II, injections of saline, piracetam, and modifiers of gamma-aminobutyric acid - aminooxyacetic acid (AOAA) and isonicotinic acid did not modify LGR. AOAA did significantly increase HGR. Thus, the preflight training has a beneficial effect in reducing disorientation in the fish in weightlessness, but the drugs employed were ineffective.
Document ID
Document Type
Reprint (Version printed in journal)
Hoffman, R. B. (NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Salinas, G. A. (NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Homick, J. L. (NASA Johnson Space Center Neurophysiology Laboratory, Houston, Tex., United States)
Date Acquired
August 10, 2013
Publication Date
June 1, 1980
Subject Category
Distribution Limits