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Record Details

Record 23 of 141
Characterization of renal response to prolonged immersion in normal man
Author and Affiliation:
Epstein, M.(Miami Univ., FL, United States)
Denunzio, A. G.(Miami Univ., FL, United States)
Ramachandran, M.(U.S. Veterans Administration, Medical Center, Miami, University)
Abstract: ?jDuring the initial phase of space flight, there is a translocation of fluid from the lower parts of the body to the central vascular compartment with a resultant natriuresis, diuresis, and weight loss. Because water immersion is regarded as an appropriate model for studying the redistribution of fluid that occurs in weightlessness, an immersion study of relatively prolonged duration was carried out in order to characterize the temporal profile of the renal adaptation to central hypervolemia. Twelve normal male subjects underwent an immersion study of 8-h duration in the sodium-replete state. Immersion resulted in marked natriuresis and diuresis which were sustained throughout the immersion period. The failure of that natriuresis and diuresis of immersion to abate or cease despite marked extracellular fluid volume contraction as evidenced by a mean weight loss of -2.2 + or - 0.3 kg suggests that central blood volume was not restored to normal and that some degree of central hypervolemia probably persisted.
Publication Date: Aug 01, 1980
Document ID:
19800062851
(Acquired Nov 30, 1995)
Accession Number: 80A47021
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Journal of Applied Physiology: Respiratory; p. vol. 49
Publisher Information: United States
Contract/Grant/Task Num: NAS9-15473
Financial Sponsor: NASA; United States
Organization Source: Miami Univ.; FL, United States
Description: 5p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AEROSPACE MEDICINE; BODY FLUIDS; MANNED SPACE FLIGHT; PHYSIOLOGICAL RESPONSES; RENAL FUNCTION; SUBMERGED BODIES; BLOOD VOLUME; BODY WEIGHT; CARDIOVASCULAR SYSTEM; DIURESIS; MALES; SODIUM; TIME DEPENDENCE; WEIGHTLESSNESS SIMULATION
Imprint And Other Notes: Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, vol. 49, Aug. 1980, p. 184-188. Research supported by the U.S. Veterans Administration;
Miscellaneous Notes: Aug. 1980, p. 184-188. Research supported by the U.S. Veterans Administration
Availability Source: Other Sources
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