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Record Details

Record 28 of 1891
Late degeneration in rabbit tissues after irradiation by heavy ions
Author and Affiliation:
Lett, J. T.(Colorado State Univ., Fort Collins, CO, United States)
Cox, A. B.(Colorado State Univ., Fort Collins, CO, United States)
Keng, P. C.(Colorado State Univ., Fort Collins, CO, United States)
Lee, A. C.(Colorado State Univ., Fort Collins, CO, United States)
Su, C. M.(Colorado State Univ., Fort Collins, CO, United States)
Bergtold, D. S.(Colorado State University, Fort Collins, Colo., United States)
Abstract: Results are presented for investigations of the late effects of heavy-ion irradiation on rabbit tissues which were undertaken to assess the hazards associated with the long-term exposure of humans to heavy ions in space during such activities as the construction of solar power stations or voyages to Mars. White rabbits approximately six weeks old were exposed to various doses of collimated beams of 400-MeV/n Ne ions, 570 MeV/n Ar ions and Co-60 gamma rays directed through both eyes, and the responses of the various tissues (hair follicles, skin, cornea, lens, retina, Harderian glands, bone and forebrain) were examined. Proliferating tissues are found to exhibit high damage levels in the early and late periods following irradiation, while terminally differentiating tissues repond to radiation most intensely in the late period, years after irradiation, with no intermediate recovery. The results obtained from rabbits are used to predict the occurrence of late tissue degeneration in the central nervous system, terminally differentiating systems and stem cells of humans one or more decades following exposure to radiation levels anticipated during long-duration space flights. The studies also indicate that tissues may be prematurely aged in the sense that tissue life spans may be shortened without the development of malignancies.
Publication Date: Jan 01, 1980
Document ID:
19800065895
(Acquired Nov 30, 1995)
Accession Number: 80A50065
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Conference Proceedings
Publication Information: (SEE A80-50051 22-51)
Publisher Information: United Kingdom
Meeting Information: Life sciences and space research. Volume 18; May 29-June 9, 1979; Bangalore; India
Contract/Grant/Task Num: NIH-AG-00005; NIH-CA-05450; NIH-CA-09236; NSG-9045
Financial Sponsor: NASA; United States
Organization Source: Colorado State Univ.; Fort Collins, CO, United States
Description: 12p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AEROSPACE MEDICINE; HEAVY IONS; ION IRRADIATION; RADIATION DAMAGE; RADIOPATHOLOGY; TISSUES (BIOLOGY); ARGON; CATARACTS; CENTRAL NERVOUS SYSTEM; DEGENERATION; EXTRATERRESTRIAL RADIATION; LONG TERM EFFECTS; NEON; RABBITS; TIME DEPENDENCE
Imprint And Other Notes: In: Life sciences and space research. Volume 18 - Proceedings of the Open Meeting of the Working Group on Space Biology, Bangalore, India, May 29-June 9, 1979. (A80-50051 22-51) Oxford and Elmsford, N.Y., Pergamon Press, 1980, p. 131-142. Research supported by the Department of Energy;
Availability Source: Other Sources
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