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Experiment K-310: The effect of spaceflight on osteogenesis and dentinogenesis in the mandibles of ratsNormal rates of dentinogenesis and osteogenesis in the body of the mandible were observed. The total calcium, inorganic phosphorus and hydroxyproline levels in the jaws and incisors of the flight rats were normal. Gravity density fractionation studies suggested, however, that spaceflight caused a delay in the normal maturation of bone mineral and matrix; normal values were reestablished by 6 days postflight. The teeth were spared. The circadian and ultradian patterns of dentin calcification were normal during spaceflight and recovery periods, but the enamel rhythms displayed a greater amplitude of sulfur concentrations and this abnormal calcium to sulfur ratios only during exposure to zero gravity. The rat mandible and teeth do not suffer the deficits of bone formation common to weight bearing parts of the skeleton during spaceflight. The only derangements detected were in the quality of the matrix and mineral moieties.
Document ID
19810024296
Acquisition Source
Legacy CDMS
Document Type
Other
Authors
Simmons, D. J.
(Washington Univ. Saint Louis, MO, United States)
Russell, J. E.
(Washington Univ. Saint Louis, MO, United States)
Winter, F.
(Washington Univ. Saint Louis, MO, United States)
Rosenberg, G. D.
(Indiana Univ. Saint Louis, MO, United States)
Walker, W. V.
(Washington Univ.)
Date Acquired
August 11, 2013
Publication Date
August 1, 1981
Publication Information
Publication: NASA. Ames Research Center US Rat Expts. Flown in the Soviet Satellite Cosmos 1129
Subject Category
Life Sciences (General)
Accession Number
81N32839
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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