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Model for antiorthostatic hypokinesia - Head-down tilt effects on water and salt excretionWater and electrolyte excretion was investigated in antiorthostatic hypokinetic and orthostatic hypokinetic and control rats in metabolic cages. Significant (t test, P less than 0.05) diuresis, natriuresis, and kaliuresis occurred in the antiorthostatic hypokinetic subjects but did not occur in either the orthostatic hypokinetic or controls. Recovery from antiorthostatic hypokinesia was characterized by retention of water, sodium, and potassium. Patterns of changes in body weight and food and water consumption were virtually identical in antiorthostatic and orthostatic hypokinetic rats and thus could not account for the differences in renal handling of water and electrolytes. Also, differences in ingestion of food and water in controls could not account for differences in excretion of water and electrolytes between these and antiorthostatic hypokinetic rats. It was concluded that the antiorthostatic position was responsible for the diuresis and natriuresis and that the antiorthostatic hypokinetic rat appears to be a good model for the study of water and elecrolyte excretion during conditions such as bed rest, water immersion, and exposure to weightlessness.
Document ID
19810026215
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Deavers, D. R.
(Louisville Univ. KY, United States)
Musacchia, X. J.
(Louisville Univ. KY, United States)
Meininger, G. A.
(Louisville, University Louisville, Ky.; Missouri-Columbia, University, Columbia, Mo., United States)
Date Acquired
August 11, 2013
Publication Date
October 1, 1980
Publication Information
Publication: Journal of Applied Physiology: Respiratory
Subject Category
Aerospace Medicine
Accession Number
81A10619
Funding Number(s)
CONTRACT_GRANT: NSG-2325
CONTRACT_GRANT: NSG-2191
Distribution Limits
Public
Copyright
Other

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