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Renal responses to central vascular expansion are suppressed at night in conscious primatesThe renal and hemodynamic responses of squirrel monkeys to central vascular volume expansion induced by lower body positive pressure (LBPP) during the day and night are investigated. Twelve unanesthetized animals trained to sit in a metabolism chair in which they were restrained only at the waist by a partition separating upper and lower body chambers were subjected to 4 h of continuous LBPP during the day and night, and hemodynamic, urinary and drinking data were monitored. LBPP during day and night is found to induce similar increases in central venous pressure, rises in heart rate and elevations in mean arterial blood pressure. However, although daytime LBPP induced a significant increase in urine flow and sodium excretion, a marked nocturnal inhibition of the renal response to LBPP is observed. Analysis of the time course and circadian regulation patterns of the urinary responses suggests that several separate efferent control pathways are involved.
Document ID
19810026371
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kass, D. A.
(Harvard Medical School Boston, MA, United States)
Sulzman, F. M.
(Harvard Medical School Boston, MA, United States)
Fuller, C. A.
(Harvard Medical School Boston, MA, United States)
Moore-Ede, M. C.
(Harvard University Boston, Mass., United States)
Date Acquired
August 11, 2013
Publication Date
October 1, 1980
Publication Information
Publication: American Journal of Physiology
Volume: 239
Subject Category
Life Sciences (General)
Accession Number
81A10775
Funding Number(s)
CONTRACT_GRANT: NSG-9054
Distribution Limits
Public
Copyright
Other

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