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Protein synthesis rates in atrophied gastrocnemius muscles after limb immobilizationNoting that protein synthesis declines in the gastrocnemius 6 hr after immobilization, the study sought to detect an increase of protein synthesis when the limb was freed, and to examine the effects of exercise on the rate of increase. Rats were used as subjects, with their hind legs in plaster of Paris in plantar flexion to eliminate strain on the gastrocnemius. Periods of immobilization were varied and samples of blood from the muscle were taken to track protein synthesis rates for different groups in immobilization and exercise regimens (running and weightlifting). Synthesis rates declined 3.6% during time in the cast, then increased 6.3%/day after the casts were removed. Both running and weightlifting were found to increase the fractional rate of protein formation in the gastrocnemius muscle when compared with contralateral muscles that were not exercised and were used as controls, suggesting that the mechanism controlling protein synthesis in skeletal muscles is rapidly responsive to changes in muscular contractile activity.
Document ID
19810057384
Document Type
Reprint (Version printed in journal)
Authors
Tucker, K. R. (Texas Univ. Houston, TX, United States)
Seider, M. J. (Texas Univ. Houston, TX, United States)
Booth, F. W. (Texas, University Houston, TX, United States)
Date Acquired
August 11, 2013
Publication Date
July 1, 1981
Publication Information
Publication: Journal of Applied Physiology: Respiratory
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NAS9-15388
CONTRACT_GRANT: PHS-AM-19393
Distribution Limits
Public
Copyright
Other