Reduction of thionucleosides - A prebiotic pathway to deoxyribonucleosidesA mechanism is proposed for the prebiotic synthesis of deoxyribonucleotides and possible nucleic acid analogs from ribonucleotides by a pathway involving 2'-thio-2'-deoxyribonucleosides. The mechanism is supported by laboratory experiments in which 2'-thio-2'-deoxycytidine was synthesized from anhydro arabinosyl cytosine in dithiophosphate and CS2. The subsequent reduction of the thio-analogs has been achieved with ferrous ion, and photochemically. It is noted that the proposed pathway for prebiotic deoxyribonucleotide synthesis is in harmony with the Principle of Continuity, as both the proposed and present pathways rely on the reduction of a 2' functional group.
Document ID
19820037393
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Patel, A. D. (Texas A&M Univ. College Station, TX, United States)
Schrier, W. H. (Texas A&M Univ. College Station, TX, United States)
Hrncir, M. A. (Texas A&M Univ. College Station, TX, United States)
Nagyvary, J. J. (Texas A & M University College Station, TX, United States)