NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Histidyl-histidine catalysis of glycine condensation in fluctuating clay environmentsHistidyl-histidine is a remarkably effective catalyst of peptide bond formation in the reaction of glycine in a fluctuating (hot-dry, cold-wet) clay environment. It has shown turnover numbers (molecules of glycine incorporated in oligoglycines per molecule of catalyst) as high as 18 in a single cycle and as high as 52 overall. A number of other dipeptides were tested, as well as monomeric histidine, N-acetyl histidine, and imidazole, none of which showed turnover numbers greater than one. Histidyl-histidine is a model for a prebiotic protoenzyme, and implications for the development of a simple translation mechanism are discussed.
Document ID
19820037417
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
White, D. H.
(Santa Clara Univ. CA, United States)
Erickson, J. C.
(Santa Clara, University Santa Clara, CA, United States)
Date Acquired
August 10, 2013
Publication Date
January 1, 1981
Subject Category
Space Biology
Meeting Information
Meeting: Origin of life
Location: Jerusalem
Country: Israel
Start Date: June 22, 1980
End Date: June 27, 1980
Accession Number
82A20952
Funding Number(s)
CONTRACT_GRANT: NCA2-OR-685-708
CONTRACT_GRANT: NCA2-OR-685-806
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available