NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
The effects of horizontal body casting on blood volume, drug responsiveness, and +Gz tolerance in the rhesus monkeyTo simulate the weightless condition, eight rhesus monkeys, instrumented with solid-state pressure transducers, were horizontally restrained in body casts for 28 days. Blood volume decreased an average of 13% after 14 days of restraint, due mainly to a drop in plasma volume. Aortic pressure and heart rate responses to norepinephrine and phenylephrine decreased after 14 days of restraint. The monkeys did not show a statistically significant decreased tolerance to a 90 deg sudden upright tilt after horizontal restraint. During the fifth week of casting, four animals were subjected to +Gz acceleration tests on a centrifuge. The acceleration tolerance of the casted monkeys was significantly reduced compared to four similarly instrumented control animals. These findings indicate that the cardiovascular deconditioning associated with simulated weightlessness results from an inability to maintain central blood volume during orthostatic stress.
Document ID
19820038147
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Dickey, D. T.
(Oklahoma Univ. Oklahoma City, OK, United States)
Billman, G. E.
(Oklahoma Univ. Oklahoma City, OK, United States)
Teoh, K.
(Oklahoma Univ. Oklahoma City, OK, United States)
Sandler, H.
(Oklahoma Univ. Oklahoma City, OK, United States)
Stone, H. L.
(Oklahoma, University Oklahoma City, OK, United States)
Date Acquired
August 10, 2013
Publication Date
February 1, 1982
Subject Category
Life Sciences (General)
Accession Number
82A21682
Funding Number(s)
CONTRACT_GRANT: NSG-2282
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available