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Modulation of human sinus node function by systemic hypoxiaThe present study was conducted to determine whether bradycardia develops during systemic hypoxia in supine conscious human volunteers when respiratory frequency and tidal volume are maintained at constant levels. The obtained results suggest that mild hypoxia provokes cardioacceleration in humans, independent of changes of ventilation or baroreflex responsiveness. The earliest cardioacceleration is more prominent in the inspiratory than in the expiratory phase of respiration, and occurs with very small reductions of arterial oxygen saturation. Moderate systemic hypoxia dampens fluctuations of heart rate during the respiratory cycle.
Document ID
19820043277
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Eckberg, D. L.
(Medical Coll. of Virginia Richmond, VA, United States)
Bastow, H., III
(Medical Coll. of Virginia Richmond, VA, United States)
Scruby, A. E.
(U.S. Veterans Administration Medical Center; Virginia, Medical College, Richmond VA, United States)
Date Acquired
August 10, 2013
Publication Date
March 1, 1982
Publication Information
Publication: Journal of Applied Physiology: Respiratory
Subject Category
Aerospace Medicine
Accession Number
82A26812
Funding Number(s)
CONTRACT_GRANT: NSG-9063
CONTRACT_GRANT: NIH-HL-22296
CONTRACT_GRANT: NIH-HL-22546
Distribution Limits
Public
Copyright
Other

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