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Changes in blood volume and response to vaso-active drugs in horizontally casted primatesExperiments were performed on horizontally casted primates (male rhesus monkeys) in order to note changes in blood volume caused by horizontal restraint, to compare orthostatic tolerance before and after casting using the responses to upright tilting, to begin to uncover the cardiovascular and neural mechanisms involved in deconditioning, and to compare the data with that obtained from bed-rested human subjects and from humans exposed to weightlessness. Bolus injections of norepinephrine of 2.0 microgram/kg, phenylephrine of 4.0 microgram/kg, and nitroprusside of 2.0 microgram/kg were administered; and aortic pressure and heart rate were recorded during the injections. The results indicate that the horizontally casted primate is a valid animal model for studying the effects of simulated zero-G on the human cardiovascular system.
Document ID
19820057122
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Dickey, D. T.
(Oklahoma Univ. Oklahoma City, OK, United States)
Teoh, K. K.
(Oklahoma Univ. Oklahoma City, OK, United States)
Sandler, H.
(Oklahoma Univ. Oklahoma City, OK, United States)
Stone, H. L.
(Oklakoma, University Oklahoma City, OK, United States)
Date Acquired
August 10, 2013
Publication Date
January 1, 1982
Publication Information
Publication: p. S-27
Subject Category
Life Sciences (General)
Accession Number
82A40657
Funding Number(s)
CONTRACT_GRANT: NSG-2282
Distribution Limits
Public
Copyright
Other

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