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Suspension restraint - Induced hypokinesia and antiorthostasis as a simulation of weightlessnessMuscle, renal, fluid and electrolyte responses were measured in suspended rats; the hind limbs are non-load bearing and the front limbs can be used for feeding and grooming. Hind limb hypokinesia reverses after removal from the suspension harness. This suspension system is adjustable for a head-down tilt to produce antiorthostatic responses which are also reversible. Responses to hypokinesia or antiorthostatic hypokinesia for up to 14 days were measured, e.g., muscle atrophy: soleus greater than gastrocnemius equals plantaris greater than extensor digitorum longus, kaliuresis, and increased excretion of urea, NH3, and 3 methylhistidine. Muscle protein loss, a response to a reduction in RNA, is also reversible. A head-down tilt for 7-14 days results in diuresis and natriuresis. These changes are reversed within 24 hours after removal from the restraint harness. Physiological effects of suspension restraint can be used to simulate and predict responses to microgravity exposure.
Document ID
19820057209
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Musacchia, X. J.
(Louisville Univ. KY, United States)
Steffen, J. M.
(Louisville, University Louisville, KY, United States)
Deavers, D. R.
(College of Osteopathic Medicine and Surgery Des Moines, IA, United States)
Date Acquired
August 10, 2013
Publication Date
January 1, 1982
Subject Category
Life Sciences (General)
Accession Number
82A40744
Funding Number(s)
CONTRACT_GRANT: NSG-2325
CONTRACT_GRANT: NSG-2191
Distribution Limits
Public
Copyright
Other

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