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Synthesis of adriamycin-coupled polyglutaraldehyde microspheres and evaluation of their cytostatic activityAdriamycin was coupled to polyglutaraldehyde microspheres having an average diameter of 4500 A. The coupled microspheres remained stable during incubation with cells. Full cytostatic activity was observed when the coupled adriamycin was tested with murine or human leukemia and murine sarcoma cell lines. A 10-fold increase in sensitivity was obtained with drug-resistant human leukemia cell lines. Repeated use of the coupled microspheres in the cytostatic assays did not decrease their activity, indicating that these complexes can be recycled. The results suggest that coupled adriamycin sufficiently perturbs the plasma membrane to lead to cytostatic activity. It is proposed that this mode of drug delivery provides multiple and repetitious sites for drug-cell interactions. In addition, the drug-polymer complexes may overcome those forms of resistance that are the result of decreased drug binding at the cell surface.
Document ID
19820063005
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Tokes, Z. A.
(University of Southern California Los Angeles, CA, United States)
Rogers, K. E.
(Southern California, University Los Angeles, CA, United States)
Rembaum, A.
(California Institute of Technology, Jet Propulsion Laboratory, Pasadena CA, United States)
Date Acquired
August 10, 2013
Publication Date
March 1, 1982
Publication Information
Publication: National Academy of Sciences
Subject Category
Life Sciences (General)
Accession Number
82A46540
Distribution Limits
Public
Copyright
Other

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