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Molecular structure of r/GCG/d/TATACGC/ - A DNA-RNA hybrid helix joined to double helical DNAThe molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA-RNA hybrid segments surrounding a central region of double helical DNA; its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2' hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities.
Document ID
19830028991
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Wang, A. H.-J.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Fujii, S.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Rich, A.
(MIT Cambridge, MA, United States)
Van Boom, J. H.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Van Der Marel, G. A.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Van Boeckel, S. A. A.
(Leiden Rijksuniversiteit, Leiden, Netherlands)
Date Acquired
August 11, 2013
Publication Date
October 14, 1982
Publication Information
Publication: Nature
Volume: 299
Subject Category
Life Sciences (General)
Accession Number
83A10209
Distribution Limits
Public
Copyright
Other

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