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Template directed reactions of 2-aminoadenylic acid derivativesThe template-directed oligomerization of activated derivatives of 2-aminoadenylic acid (paA) on polyuridylic acid (poly(U)) in aqueous buffers was studied. The reaction differs from that of adenylic acid (pA) under identical conditions, in that only di- and tri-nucleotides are observed as substantial products rather than a longer sequence of oligomers. The reaction of paA also differs from that of pA in that it does not require Mg (2+), and is less susceptible to increased temperature. The relevance of these observations to the chemical evolution of polynucleotide replication is discussed. Improved syntheses of paA and its diphosphate are reported.
Document ID
19830030624
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Webb, T. R.
(Salk Inst. for Biological Studies San Diego, CA, United States)
Orgel, L. E.
(Salk Institute for Biological Studies San Diego, CA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1982
Publication Information
Publication: Nucleic Acids Research
Volume: 10
Issue: 14, 1
Subject Category
Chemistry And Materials (General)
Accession Number
83A11842
Funding Number(s)
CONTRACT_GRANT: NGR-05-067-001
Distribution Limits
Public
Copyright
Other

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