NASA Logo, External Link
Facebook icon, External Link to NASA STI page on Facebook Twitter icon, External Link to NASA STI on Twitter YouTube icon, External Link to NASA STI Channel on YouTube RSS icon, External Link to New NASA STI RSS Feed AddThis share icon
 

Record Details

Record 20 of 140
Short term /1 and 3 day/ cardiovascular adjustments to suspension antiorthostasis in rats
Author and Affiliation:
Musacchia, X. J.(Louisville Univ., KY, United States)
Steffen, J. M.(Louisville, University, Louisville, KY, United States)
Abstract: Antiorthostasis (AO) results in responses reflective of thoracic vessel loading. Initial findings included fluid and electrolyte shifts (diuresis and natriuresis) in AO but not in orthostatic (O) rats. This study aims at obtaining supportive evidence for cardiovascular responses, E.g., blood pressure and related parameters, in light of the original hypothesis. Tilting rats rapidly head-up from either horizontal (O) or head-down (AO) positions was used to assess cardiovascular sensitivities. O and AO rats were used after 1 or 3 days of suspension. Rats were controls (C), pre-tilted O and AO, tilted O and AO (rapid head-up 70-80 deg); post-tilted (to original postures). MAP in C rats was 108 +2 mmHg, in O, (117 + or - 1.02) and AO, (120 + or - 0.58). MAP, diastolic pressure (DP) and pulse pressure were consistently elevated in AO rats on day 3. With rapid head-up tilt, only MAP and DP showed significant increases. These changes were seen as cardiovascular responses to AO and support further use of this rat model for AO studies.
Publication Date: Dec 01, 1982
Document ID:
19830046624
(Acquired Nov 30, 1995)
Accession Number: 83A27842
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publisher Information: United States
Contract/Grant/Task Num: NSG-2325
Financial Sponsor: NASA; United States
Organization Source: Louisville Univ.; KY, United States
Description: 2p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BED REST; HEMODYNAMIC RESPONSES; HYPOKINESIA; ORTHOSTATIC TOLERANCE; BLOOD PRESSURE; HEAD DOWN TILT; RATS
Imprint And Other Notes: (International Union of Physiological Sciences, Annual Meeting, 4th, San Diego, CA, Oct. 10-15, 1982.) Physiologist, Supplement, vol. 25, Dec. 1982, p. S-163, S-164.
Availability Source: Other Sources
› Back to Top
Find Similar Records
NASA Logo, External Link
NASA Official: Gerald Steeman
Site Curator: STI Program
Last Modified: August 17, 2011
Contact Us