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Opposing actions of dibutyryl cyclic AMP and GMP on temperature in conscious guinea-pigsIt is shown that the intracerebroventricular administration of dibutyryl cyclic AMP (Db-cAMP) induced hyperthermia in guinea pigs which was not mediated through prostaglandins or norepinephrine since a prostaglandin synthesis inhibitor and an alpha-adrenergic receptor blocking agent did not antagonize the hyperthermia. However, the hyperthermic response to Db-cAMP was attenuated by the central administration of a beta-adrenergic receptor antagonist, which indicates that cAMP may be involved, through beta-adrenergic receptors, in the central regulation of heat production and conservation. The central administration of Db-cGMP produced hypothermia which was not mediated via histamine H1 or H2 receptors and serotonin. The antagonism of hypothermia induced by Db-cGMP and acetylcholine + physostigmine by central administration of a cholinergic muscarine receptor antagonist and not by a cholinergic nicotinic receptor antagonist suggests that cholinoceptive neurons and endogenous cGMP may regulate heat loss through cholinergic muscarine receptors. It is concluded that these results indicate a regulatory role in thermoregulation provided by a balance between opposing actions of cAMP and cGMP in guinea pigs.
Document ID
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Kandasamy, S. B.
(NASA Ames Research Center Moffett Field, CA, United States)
Williaes, B. A.
(NASA Ames Research Center Biosystems Div., Moffett Field, CA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Neuropharmacology
Volume: 22
ISSN: 0028-3908
Subject Category
Life Sciences (General)
Accession Number
Distribution Limits

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