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Record Details

Record 18 of 2413
Biochemical changes in rat liver after 18.5 days of spaceflight (41566)
Author and Affiliation:
Abraham, S.(Childrens Hospital Medical Center of Northern California, Oakland, CA, United States)
Lin, C.Y.(Children's Hospital Medical Center, Oakland, CA, United States)
Volkmann, C. M.(Childrens Hospital Medical Center of Northern California, Oakland, CA, United States)
Klein, H. P.(NASA Ames Research Center, Moffett Field, CA, United States)
Abstract: The effect of weightlessness on liver metabolism was investigated using tissue from rats flown in earth orbit for 18.5 days on the Soviet Cosmos 936 biosatellite and the changes in the activities of 28 carbohydrate and lipid enzymes were determined. The activities of two enzymes, palmitoyl-CoA desaturase and lactate dehydrogenase, increased, while the activities of five, glycogen phosphorylase, 6-phosphogluconate dehydrogenase, both acyltransferases which act on alpha-glycerolphosphate and diglycerides, and and aconitate hydratase decreased. The other enzyme activities were found to be unchanged. In addition, increased levels of liver glycogen and palmitoleate were detected which probably resulted from the lowered glycogen phosphorylase and increased palmitoyl-CoA desaturase activities, respectively, in those animals that experienced weightlessness. All of the changes observed in the rats after 18.5 days of spaceflight disappear by 25 days after the flight.
Publication Date: Jan 01, 1983
Document ID:
19830048328
(Acquired Nov 30, 1995)
Accession Number: 83A29546
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Society for Experimental Biology and Medicine, Proceedings (ISSN 0037-9727); 172; 1983
Publisher Information: United States
Contract/Grant/Task Num: NAS2-9523
Financial Sponsor: NASA; United States
Organization Source: Childrens Hospital Medical Center of Northern California; Oakland, CA, United States
NASA Ames Research Center; Moffett Field, CA, United States
Description: 6p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: CARBOHYDRATE METABOLISM; LIPID METABOLISM; LIVER; PHYSIOCHEMISTRY; PHYSIOLOGICAL EFFECTS; WEIGHTLESSNESS; AEROSPACE MEDICINE; COSMOS 936 SATELLITE; ENZYME ACTIVITY; RATS; SPACEBORNE EXPERIMENTS
Imprint And Other Notes: Society for Experimental Biology and Medicine, Proceedings (ISSN 0037-9727), vol. 172, 1983, p. 334-339.
Miscellaneous Notes: p. 334-339
Availability Source: Other Sources
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