NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Human respiration at rest in rapid compression and at high pressures and gas densitiesThe ventilation (V), end-tidal PCO2 (PACO2), and CO2 elimination rate were determined in men at rest breathing CO2-free gas over the pressure range 1-50 ATA and the gas density range 0.4-25 g/l, during slow and rapid compressions, at stable elevated ambient pressures and during slow decompressions. Progressive increase in pulmonary gas flow resistance due to elevation of ambient pressure and inspired gas density to the He-O2 equivalent of 5000 feet of seawater was found to produce a complex pattern of change in PACO2. It was found that as both ambient pressure and pulmonary gas flow resistance were progressively raised, PACO2 at first increased, went through a maximum, and then declined towards values near the 1 ATA level. It is concluded that this pattern of PACO2 change results from the interaction on ventilation of the increase in pulmonary resistance due to the elevation of gas density with the increase in respiratory drive postulated as due to generalized central nervous system excitation associated with exposure to high hydrostatic pressure. It is suggested that a similar interaction exists between increased gas flow resistance and the increase in respiratory drive related to nitrogen partial pressure and the resulting narcosis.
Document ID
19830049249
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gelfand, R.
(Pennsylvania Univ. Philadelphia, PA, United States)
Lambertsen, C. J.
(Pennsylvania Univ. Philadelphia, PA, United States)
Strauss, R.
(Pennsylvania Univ. Philadelphia, PA, United States)
Clark, J. M.
(Pennsylvania Univ. Philadelphia, PA, United States)
Puglia, C. D.
(Pennsylvania, University Philadelphia, PA, United States)
Date Acquired
August 11, 2013
Publication Date
January 1, 1983
Publication Information
Publication: Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
Volume: 54
ISSN: 0161-7567
Subject Category
Aerospace Medicine
Accession Number
83A30467
Funding Number(s)
CONTRACT_GRANT: N00014-67-A-0216-0026
CONTRACT_GRANT: NSG-90011
CONTRACT_GRANT: N00014-76-C-0248
CONTRACT_GRANT: N00014-75-C-1124
CONTRACT_GRANT: NIH-HL-08899-11
CONTRACT_GRANT: NIH-HL-08899-08
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available