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Sympathoadrenal responses to cold and ketamine anesthesia in the rhesus monkeyThe effect of cold exposure on the sympathoadrenal system is investigated in eight adult rhesus monekys with and without ketamine anesthesia. It is found that a 3 hr cold exposure (12 c) was associated with a 175 percent increase above control levels of norepinephrine (NE) and a 100 percent increase in epinephrine (E). Also observed were decreases in the core temperature, mean skin temperature, and mean body temperature. No change in the plasma levels of NE and E from the control values was found during continuous infusion of ketamine; while the core temperature, mean skin temperature, and mean body temperature all showed greater declines with the addition of ketamine infusion to the cold exposure. Water exposure (28 C) under ketamine anesthesia resulted in a reduction of the core temperature to 33 C within 1 hr. Plasma levels of NE and E were found to be unchanged from control values at core temperatures of 35 and 33 C. It is concluded that the administration of ketamine abolishes both the thermoregulatory response and the catecholamine response to acute cold exposure.
Document ID
19830049278
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kolka, M. A.
(Indiana Univ. Bloomington, IN, United States)
Elizondo, R. S.
(Indiana Univ. Bloomington, IN, United States)
Weinberg, R. P.
(Indiana University Bloomington, IN, United States)
Date Acquired
August 11, 2013
Publication Date
April 1, 1983
Publication Information
Publication: Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
Volume: 54
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
83A30496
Funding Number(s)
CONTRACT_GRANT: NIH-AM-16703
Distribution Limits
Public
Copyright
Other

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